Effect of Neutralizing Sera on Factor X-Mediated Adenovirus Serotype 5 Gene Transfer
نویسندگان
چکیده
منابع مشابه
Effect of neutralizing sera on factor x-mediated adenovirus serotype 5 gene transfer.
The deployment of adenovirus serotype 5 (Ad5)-based vectors is hampered by preexisting immunity. When such vectors are delivered intravenously, hepatocyte transduction is mediated by the hexon-coagulation factor X (FX) interaction. Here, we demonstrate that human sera efficiently block FX-mediated cellular binding and transduction of Ad5-based vectors in vitro. Neutralizing activity correlated ...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2009
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.01878-08